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PH525.8x: Case study: DNA methylation data analysis

Harvard University via edX

2 Reviews 124 students interested

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Overview

In the PH525 case studies, we will explore the data analysis of an experimental protocol in depth, using various open source software, including R and Bioconductor. We will explain how to start with raw data, and perform the standard processing and normalization steps to get to the point where one can investigate relevant biological questions. Throughout the case studies, we will make use of exploratory plots to get a general overview of the shape of the data and the result of the experiment.

We will learn the basic steps in analyzing DNA methylation data, including reading the raw data, normalization, and finding regions of differential methylation across multiple samples.

This class was supported in part by NIH grant R25GM114818.

This course is part of a larger set of 8 total courses running Self-Paced through September 15th, 2015:PH525.1x: Statistics and R for the Life Sciences

PH525.2x: Introduction to Linear Models and Matrix Algebra

PH525.3x: Advanced Statistics for the Life Sciences

PH525.4x: Introduction to Bioconductor

PH525.5x: Case study: RNA-seq data analysis

PH525.6x: Case study: Variant Discovery and Genotyping

PH525.7x: Case study: ChIP-seq data analysis

PH525.8x: Case study: DNA methylation data analysis

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Taught by

Michael Love and Rafael Irizarry

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Reviews for edX's PH525.8x: Case study: DNA methylation data analysis
4.5 Based on 2 reviews

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Brandt P
4.0 3 years ago
by Brandt completed this course, spending 4 hours a week on it and found the course difficulty to be medium.
(Note, these case studies seem to have been combined into one course recently).

This is the fourth and final case study and 8th and final course overall in the PH525 sequence. This was the most useful case study course in the sequence of the three I've taken (I skipped the course on variant discovery due to its reliance on a Linux virtual machine, although I will probably go back and complete that course at some point). One of Dr. Irizarry's research areas involves analysis of DNA methylation through various techniques, and as a result the material in this course is somewhat bette…
Was this review helpful to you? Yes
Xlwudw X
5.0 2 years ago
by Xlwudw completed this course.
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