With the emergence of high throughput DNA sequencing technologies, the complete genome sequences of many organisms are deciphered and are being analyzed. Despite the progress, understanding the cellular functions of most the genes thus identified remains a challenge. The emerging field of “Functional Genomics” aims at providing comprehensive approaches to understand the genome functions, to develop and promote high throughput and large scale approaches to investigate the function of the genomes, their products and the interactions between the two. This course thus will provide an overview of the concept of Functional Genomics and contemporary approaches used to understand the genome function. Intended Audience
Students interested in pursuing research in genomics and biotechnology field.
Medical students and practicing clinicians interested in genomics and molecular medicine.
Students interested in careers in biotechnology and biopharma fields.
Technical staff /scientists working in biotechnology, biopharma and molecular diagnostic laboratories/industry
Week 1: [2 hrs; 6 x 20 min] Introduction to functional genomics; Large-scale approaches to investigating gene/protein function: rationale and advantages;
Week 2: [3 hrs; 6 x 30 min] Predicting gene function based on DNA sequence: motif analyses and tools for homology-based identification; Transcriptomics: overview of past and current technologies
Week 3: [3 hrs: 6 x 30 min] High-throughput genetic approaches to assessing gene function (e.g. large-scale mutant libraries, RNAi, genome editing, chemical genomics)
Week 4: [2 hrs: 6 x 20 min] Connecting Traits to Genes, and Genes to Functions; Comparative Genomics
MOOCs stand for Massive Open Online Courses. These arefree online courses from universities around the world (eg. StanfordHarvardMIT) offered to anyone with an internet connection.
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