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The course covers an advance level of organometallic chemistry. Recent development of cross coupling reactions and their applications in organic synthesis, starting from small molecule to naturally and pharmaceutically important compounds, has been described in the prescribed course. In this course, a brief overview about the carbine chemistry and oxidative cyclization is also portrayed.INTENDED AUDIENCE: Students, PhD scholars, teachers, industry.PREREQUISITES: Advance Organic and Inorganic Chemistry.INDUSTRY SUPPORT: All Pharmaceutical Industries.