subject
Intro

edX: Principles of Biochemistry

 with  Rachelle Gaudet and Alain Viel

Principles of Biochemistry integrates an introduction to the structure of macromolecules and a biochemical approach to cellular function. Topics addressing protein function will include enzyme kinetics, the characterization of major metabolic pathways and their interconnection into tightly regulated networks, and the manipulation of enzymes and pathways with mutations or drugs. An exploration of simple cells (red blood cells) to more complex tissues (muscle and liver) will be used as a framework to discuss the progression in metabolic complexity. Learners will also develop problem solving and analytical skills that are more generally applicable to the life sciences.

New in version 2, learners will explore how alteration of these metabolic pathways relates to the development and progression of some human diseases.


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Harvard University and HarvardX are committed to maintaining a safe and healthy educational and work environment in which no member of the community is excluded from participation in, denied the benefits of, or subjected to discrimination or harassment in our program. All members of the HarvardX community are expected to abide by Harvard policies on nondiscrimination, including sexual harassment, and the edX Terms of Service. If you have any questions or concerns, please contact harvardx@harvard.edu and/or report your experience through the edX contact form.

Image credit: PDB ID 2DN1, 2DN2

Park S-Y, Yokoyama T, Shibayama N, Shiro Y, Tame JRH (2006) 1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms. J Mol Biol 360: 690–701.

Syllabus

Unit 1: Introduction to biochemistry
● Course introduction
● Review of basic biochemistry

Unit 2: Structural biochemistry
● Protein structure
● Protein folding
● Enzyme catalysis
● Enzyme kinetics and iterative saturation mutagenesis
● Lipid structure and membrane assembly

     ○ Human disease focus: lipodystrophy and lipid droplet pathologies
● Carbohydrate structure

Unit 3: Cellular bioenergetics
● Glycolysis
● Unique features of glycolysis in red blood cells
● Bacterial energetics
● The citric acid and glyoxylate cycles
● Electron transport
● ATP synthesis
● Regulation of glycolysis in liver cells
● Regulation of blood sugar by the liver
     ○ Human disease focus: diabetes

Unit 4: Tissue-specific metabolism
● Liver metabolism
● Muscle metabolism
● Brain metabolism
     ○ Human disease focus: PKU

Unit 5: Synthesis and degradation of biomolecules
● Nucleic acids
● Carbohydrate metabolism
     ○ Human disease focus: G6PD deficiency
● Fatty acid metabolism
● Human disease focus: cancer and cachexia

4 Student
reviews
Cost Free Online Course
Pace Upcoming
Subject Biology
Institution Harvard University
Provider edX
Language English
Hours 4-6 hours a week
Calendar 15 weeks long

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4 reviews for edX's Principles of Biochemistry

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5 out of 6 people found the following review useful
2 years ago
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Anonymous is taking this course right now.
A fantastic introduction to biochemistry. If you've every struggled to understand the basics of biochemistry then this is the course for you. If you just starting to study biochemistry you would have to work a lot in this course, but lectures are just amazing, explanations are clear.
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1 out of 2 people found the following review useful
2 years ago
Jonathan Golland completed this course.
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9 months ago
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Chandler Palmer partially completed this course.
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a year ago
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Martin Nilsson completed this course.
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