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Thyroid Eye Disease - Understanding the Disease and New Treatments
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- 1 Intro
- 2 Thyroid Eye Disease: Understanding the Disease & New Treatments Andrea Lora Kossler, MD, FACS
- 3 OUTLINE
- 4 GRAVES DISEASE THE SYSTEMIC COMPONENTS
- 5 THYROID EYE DISEASE (TED)
- 6 AUTOIMMUNE DISEASE
- 7 KEY PLAYER TED: THE ORBITAL FIBROBLAST
- 8 TED PATHOPHYSIOLOGY
- 9 TED IS ASSOCIATED WITH SIGNIFICANT VISION-THREATENING IMPAIRMENTS
- 10 EYELID RETRACTION 911
- 11 DIPLOPIA (DOUBLE VISION) 43-51%
- 12 TED HAS BROAD IMPLICATIONS FOR PATIENTS' LIVES
- 13 MILD TED
- 14 LIMITED WINDOW FOR TREATMENT1-3
- 15 TREATMENT: MULTIDISCIPLINARY APPROACH
- 16 CASE 1: 67 YEAR OLD FEMALE WITH EYE REDNESS, SWELLING, & PAIN X 2 MONTHS
- 17 CURRENT MANAGEMENT OPTIONS FOR TED
- 18 STEROIDS WERE THE PREVIOUS GOLD STANDARD TREATMENT
- 19 MEDICAL THERAPY: ORBITAL RADIATION
- 20 VISION THREATENING TED
- 21 TREATMENT-COMPRESSIVE OPTIC NEUROPATHY
- 22 CASE 2: 45 YO MALE TED, PROPTOSIS OU, DOUBLE VISION, PAIN, SWELLING AND LOSS OF VISION
- 23 BIOLOGIC THERAPY
- 24 TEPROTUMUMAB RESPONSE
- 25 OPTIC (PHASE 3) PROSPECTIVE RANDOMIZED TRIAL
- 26 SURGERY IS CURRENTLY THE MAIN OPTION FOR FIBROTIC TED
- 27 27 FEMALE PROPTOSIS AND LAGOPHTHALMOS
- 28 EYELID CREASE INCISION
- 29 POST OP WEEK 3 SP LATERAL WALL DECOMPRESSION
- 30 CONCLUSION- THYROID EYE DISEASE
