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Tales from the Genome

23andme via Udacity

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Overview

This course is a journey into the biology of the human genome and will highlight the scientific, social, and personal perspectives of people living with a variety of traits.



Why Take This Course?

You will learn about fundamental principles of inheritance, gene expression, mutation and variation, development of simple and complex biological traits, human ancestry and evolution, and the acquisition of personal genetic information. By the end of this course, you will be able to read and understand genetic information available from personal genetics services such as 23andMe.

Syllabus

Lesson 1: Introduction to traits and heredity

Trait variation and categorization, basic models of inheritance, and the connection via DNA. Check out the concept map for this lesson.

Lesson 2: Defining the genome

DNA structure, chromosomes, and genome organization. Check out the concept map for this lesson.

Lesson 3: How a genome works

Protein coding genes, transcription, translation, discerning the genetic code, and alleles. Check out the concept map for this lesson.

Lesson 4: Gene regulation

Non-coding DNA, regulatory regions of genes, and transcription factors. Check out the concept map for this lesson.

Lesson 5: Transmission of genes and traits

Family relationships and pedigrees, inheritance patterns, allele dominance, and chromosome dynamics. Check out the concept map for this lesson.

Lesson 6: Origin of mutation/variation

Types of mutations, various causes of mutation, allelic frequency, and the spread of alleles in a population. Check out the concept map for this lesson.

Lesson 7: How to obtain and interpret personal genetic information

Personalized genetics: sample acquisition, DNA extraction and processing, and interpretation of results. Check out the concept map for this lesson.

Lesson 8: Simple genetic traits

Molecular causes of monogenic traits, loss-of-function vs. gain-of-function alleles, and dominance. Check out the concept map for this lesson.

Lesson 9: Multifactorial traits

Polygenic traits, complex traits with an environmental effect, qualitative and quantitative measures, twin studies, relative risk, and genome-wide association studies (GWAS). Check out the concept map for this lesson.

Lesson 10: Pharmacogenetics: genes and drugs

Pharmacokinetics and pharmacodynamics, alleles affecting drug metabolism, and personalized medicine. Check out the concept map for this lesson.

Lesson 11: Human ancestry and evolution

Identity by state (IBS), Identity by descent (IBD), relative finder, maternal and paternal lineages, neanderthal interbreeding, and human/chimp evolution. Check out the concept map for this lesson.

Lesson 12: The immortal genome (putting genetics to work)

Personal decisions, legal questions, professional options, and the future of genetics. Check out the concept map for this lesson.

Bonus Lesson: Discovering DNA in your Kitchen

Using only normal household items, even YOU can extract DNA and see it live and in person. At the end of this lesson you'll have the best new party trick EVER. (just remember to bring strawberries) Here is the protocol/procedure to make it happen.

Taught by

Matthew Cook

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Reviews for Udacity's Tales from the Genome
4.6 Based on 5 reviews

  • 5 stars 60%
  • 4 stars 40%
  • 3 star 0%
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  • 1
Anonymous
5.0 5 years ago
Anonymous completed this course.
A fantastic introduction to genetics for beginners. If you've every struggled to understand the basics of genetics then this is the course for you. It was developed in collaboration with people at 23andMe, so a bonus is that you will be able to better understand the results of your personal genetics kit if you get one from 23andMe.
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this review helpful
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Greg C
5.0 4 years ago
Greg completed this course, spending 6 hours a week on it and found the course difficulty to be easy.
This course is a good introduction to various aspects of genetics, with an emphasis on understanding personal genotype data as presented by 23andme. The instructors have a very engaging style that actually takes advantage of the format instead of being a video of a talking head, as some courses still are.
2 people found
this review helpful
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John C
4.0 4 years ago
John completed this course, spending 6 hours a week on it and found the course difficulty to be medium.
ties to 23andme was a little bit distracting but I assumed that might be the case going into the study
1 person found
this review helpful
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Chris E
5.0 4 years ago
Chris completed this course, spending 2 hours a week on it and found the course difficulty to be medium.
2 people found
this review helpful
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Patricia A
4.0 3 years ago
by Patricia completed this course, spending 20 hours a week on it and found the course difficulty to be medium.
1 person found
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