This course aims to introduce learners to the Human Cell Atlas project, which seeks to create a comprehensive map of human cells. The course covers topics such as the central dogma of cells, gene expression profiles, and the importance of understanding cells to comprehend disease-causing genes. Learners will also explore specific test cases, such as the airways and zebrafish development, to understand cell diversity and transitions. The teaching method involves lectures and case studies, with a focus on the application of algorithms in cell research. This course is intended for individuals interested in personalized medicine, cell biology, genomics, and bioinformatics.
Overview
Syllabus
Intro
Cells are our basic units
The central dogma
Cells express the genes they need at the right quantities
A gene expression profile is the calling card of a cell
Knowing our cells is essential to understand the genes that cause disease
Gene expression: coordinates for a map of all human cells
Test case: the airways
Test case: Zebrafish development
A cell tree for zebrafish embryogenesis
Tracing blood formation in humans
Algorithms allow us to "play back the tape"
Immunotherapies are the most important therapeutic advance in cancer care, but...
New proposed option for combination treatment
Test case: Inflammatory bowel disease
A single cell atlas of the colon of healthy and UC patients
A map across multiple diseases
Human Cell Atlas: Mission
HCA principles and values
Large scale, international funding for data collection, method development, and data platform
Phase 1: the first draft
Taught by
The Aspen Institute
