Organic Chemistry in Biology and Drug Development

NPTEL and Indian Institute of Technology, Kharagpur via YouTube

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Provider

YouTube
Pricing

Free Online Course
Languages

English
Duration & workload

1 day 18 hours
Sessions

On-Demand

Found in

Overview

COURSE OUTLINE: In the biosphere, the chemistry must be considered in the context of the cell, or an organ, or even a whole organism. That makes mimicking of biological processes to be extremely challenging as the reaction needs to be performed with perfect orthogonality to other functional entities present in a biological system. Today, with the advancement of various spectroscopic and molecular biology techniques and with a better understanding of chemical principles, functions of various bio molecules have been unravelled which has paved the way for development of newer drugs. The present course is an attempt to bridge the gap in our understanding of biological systems and processes at the molecular and functional level. The course first introduces the various kinds of bio molecules, macro to medium size to small, their structures and functions followed by molecular engineering to manipulate their activity and biosynthesis. That creates a perfect platform for the next module on drug design and discovery.

Syllabus

Organic Chemistry in Biology and Drug Development.
Lecture 1 : A brief introduction to Molecules of Life.
Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions.
Lecture 3 : Amino Acids: The building block of proteins.
Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction.
Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein.
Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods.
Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality.
Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods.
Lecture 9 : Recent development of coupling agents;.
Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure.
Lecture 11 : Ramachandran plot and protein purification techniques.
Lecture 12 : Protein Purification Techniques (Contd.).
Lecture 13 : Introduction to Enzymes and its kinetics.
Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases.
Lecture 15 : Enzyme Kinetics (Contd.).
Lecture 16 : Concept of Enzyme Inhibition.
Lecture 17 : Concept of Enzyme Inhibition (Contd.).
Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition.
Lecture 19 : Synthetic Biology.
Lecture 20 : Synthetic Biology (Contd.).
Lecture 21 : Synthetic Biology (Contd.).
Lecture 22 : Nucleic Acid.
Lecture 23 : Nucleic Acid (Contd.).
Lecture 24 : DNA sequencing method.
Lecture 25 : DNA sequencing method (Contd.).
Lecture 26 : DNA sequencing method (Contd.).
Lecture 27 : Synthesis of oligonucleotide.
Lecture 28 : Central dogma: DNA replication, transcription and translation.
Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.).
Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 33 : Molecular Biology.
Lecture 34 : Molecular Biology (Contd.).
Lecture 35 : Chemistry of cofactors/coenzymes.
Lecture 36 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 37 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 38 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 39 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 40 : Chemistry of cofactors/coenzymes (Contd.).
Lecture-41: " Introduction to Drug Discovery Process".
Lecture-42: " Fundamental Principles of Drug Development Process".
Lecture-43: " Combinatorial chemistry".
Lecture-44: "Neurotransmitters".
Lecture-45: " Catechol amine based and GABA neurotransmitters".
Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system".
Lecture-47: " Inhibitor design of angiotensin converting enzyme".
Lecture 48: Antimicrobial drugs.
Lecture 49: Chemistry of penicillins.
Lecture 50: Resistance to beta-lactam antibiotics.
Lecture 51: Mechanistic studies of beta-lactamase.
Lecture 52: Non beta-lactam antibiotics.
Lecture 53: Mechanistic enzymology of Isopenicillin N synthase.
Lecture-54 : Polyketide Biosynthesis.
Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus.
Lecture 56 : Anti-viral drugs.
Lecture-57 : Cancer and Chemotherapy.
Lecture-58 : Anti-cancer drugs (contd).
Lecture 59 : Aromatase inhibition and Anti-ulcer drugs.
Lecture-60 : Cholesterol lowering agents.
Lecture 61 : Cholesterol Biosynthesis.
Lecture-62 : Pharmakinetics and pharmadynamics.
Lecture-63 : QSAR principles.

Taught by

IIT Kharagpur July 2018

Reviews

4.5 rating, based on 26 Class Central reviews

Start your review of Organic Chemistry in Biology and Drug Development

Rafia Imran @RI21

good course, understood everything taught in depth. highly recommended. I was specifically looking for this course and was happy to learn from it
Priyanuj Parasar

As an avid learner in the realm of biology and drug development, I recently embarked on a journey through the online course "Organic Chemistry in Biology and Drug Development." This course promised to unravel the intricate connections between organi…

As an avid learner in the realm of biology and drug development, I recently embarked on a journey through the online course "Organic Chemistry in Biology and Drug Development." This course promised to unravel the intricate connections between organic chemistry principles and their applications in the fields of biology and pharmaceuticals.
First and foremost, the course structure was commendable. Each module was meticulously organized, starting from the fundamentals of organic chemistry and gradually delving into its pivotal role in understanding biological processes and drug design. The seamless progression allowed for a comprehensive grasp of the subject matter, catering to both novices and those with prior knowledge.
Moreover, the course materials were rich and varied, comprising video lectures, supplementary readings, and interactive simulations. This multimodal approach catered to different learning preferences, ensuring that all participants could absorb the content effectively.

In terms of improvements, while the course covered a broad spectrum of topics, there was room for more in-depth exploration of certain areas, particularly advanced organic synthesis strategies and cutting-edge drug development techniques. Additionally, incorporating more opportunities for hands-on experimentation or virtual laboratory simulations could further enhance the learning experience.
Muhammed Sanil.c

The course on Organic Chemistry in Biology and Drug Development provides a comprehensive exploration of key concepts linking organic chemistry to the fields of biology and drug discovery. The material is presented in a clear and engaging manner, making complex topics accessible. The incorporation of real-world examples and case studies enhances the practical relevance of the content. The instructors demonstrate a strong command of the subject matter, fostering a positive learning experience. Overall, this course serves as a valuable resource for understanding the pivotal role of organic chemistry in advancing biological and pharmaceutical sciences.
Aslan Yalcin KURT

The Professor, conducted the class exceptionally well. His clear and precise explanations facilitated a thorough understanding of complex topics. The lecture structure was well thought out, making it easy for us to follow the material. The interactive nature of the classes was particularly impressive, enhancing knowledge retention. Supportive materials and practical examples further enriched the learning experience. Overall, it was an extremely educational journey that significantly enhanced my academic capabilities. I appreciate him/ Professor dedication and effectiveness, and I wholeheartedly recommend his courses. Best regards kurt
Shinde Swapnil Shivaji

Very helpful course . I learnt a lot of things form this course .it will help mi lot of in my carrear . Really thankful for giving importannt information to mi. Thank you very much.as a student this course help mi a lot . Learn many things from this . And whenever information needed i again come and see this course video for learning new things . I completed all chapters of this course with very consentration
Okoye Paschal Kenechukwu

I like the method of teaching, it is very fascinating and exciting for young chemists who are willing to specialize in the field of medicinal chemistry. A step by step approach and breakdown for learning. It's worth it...

I'm very grateful for this opportunity and delightful. I want to acknowledge the professor who has taken his time to teach meticulously
Bhagyashri Bhanudas Gunjal

It's a very nice course. I have learn very much about drug from this course. I'm very lucky to be a learner of this course Thank you so much
Pagare Dayali

Very helpful.. thanks for arranging this course .I enjoyed the content, and the data is very helpful for my current course.thank you
Roshni Qayyum

I enjoy this course very much. I gain a lot of knowledge from this course this will surely help me in my future
Tehreem

very nice and informative. i gained very helpful information from this course . this course is must view.
Laxman Kumar Prajapat

excellent, well explained by amit basak sir. after this course i have much knowledge abou organic chemistry
Hiba K H

Very helpful and by this i understand the importance of the subject chemistry in drug development and this also helped me to understand the reaction that will help to give Harmony in humans
Assem Tabboush

This course of Organic Chemistry in Biology and Drug Development offered a perceptive investigation of the significant contribution organic chemistry has made to the development of biology and medicines. The course material successfully merged basic organic chemistry concepts with how they are used in medication development. The course clarified how molecular structures affect biological interactions and therapeutic efficacy through interesting lectures and real-world examples. Although demanding at times, the thorough information and the instructor's concise explanations encouraged a greater grasp of this difficult subject. Overall, the course helped students understand how organic chemistry affects healthcare in the actual world.
YATHEESH KODIGEHALLI NANDAKUMAR

Organic chemistry plays a crucial role in both biology and drug development. In biology, organic compounds such as carbohydrates, lipids, proteins, and nucleic acids are essential components of living organisms. Organic chemistry provides the unders…

Organic chemistry plays a crucial role in both biology and drug development. In biology, organic compounds such as carbohydrates, lipids, proteins, and nucleic acids are essential components of living organisms. Organic chemistry provides the understanding of the structure and function of these biological molecules and how they interact with each other to maintain life.

In drug development, organic chemistry is used to design and synthesize new compounds with desired biological activities. The knowledge of organic chemistry allows scientists to modify the structure of a molecule to enhance its potency and selectivity as a drug candidate. Organic chemistry is also crucial in the production of drugs, as it provides the methods for large-scale synthesis and purification of active pharmaceutical ingredients.

Overall, the study of organic chemistry is essential for a deeper understanding of biological processes and the development of new drugs to treat various diseases.
Divyanshu Raturi

This is a very great course in "organic chemistry in biology and drug development" .In this course they have explained everything from the beginning and with alot of examples that we all could relate with, And they have explained all the complicated topic with much easier language.
Yadav Khushboo Vijay

Session was informative and engaging. It helped me in learning chemistry in different way. Organic chemistry in drug development is very important thus it is very important to learn every aspect of chemistry. This session helped me in learning every aspect of it.
SUMI B

I got more knowledge about organic chemistry in Biology and drug development. Lectures are teaches in a good manner.
Anonymous

Bio-molecules such as proteins, sugars, fats, and nucleic acids (DNA and RNA) are all organic molecules, albeit very large ones
Chemistry for drug discovery: All pharmaceutical products contain organic molecules, which may be sourced from natural products or be fully synthetic molecules. Thus, organic chemistry underpins both existing and upcoming pharmaceutical products

Knowledge of Chemistry plays a crucial role in predicting drug interactions.
56 NIKITA VHALGADE

This is the best platform for new learners.

I'm very grateful for this opportunity and delightful. I want to acknowledge the professor who has taken his time to teach.
Brijesh Kumar Sharma

Subject matter was awesome.all points related to biochemistry, molecular biology and others.
The instructor clearly focused on all the topics.
Thanks for all.