NPTEL: Bioinformatics: Algorithms and Applications

 with  M Michael Gromiha

Bioinformatics is an interdisciplinary field of science for analyzing and interpreting vast biological data using computational techniques. In this course, we aim to give a walkthrough of the major aspects of bioinformatics such as the development of databases, computationally derived hypothesis, algorithms, and computer-aided drug design. During the first section of the course, we will focus on DNA and protein sequence databases and analysis, secondary structures and 3D structural analysis. The second section will be devoted to applications such as prediction of protein structure, folding rates, stability upon mutation, and intermolecular interactions. Further, we will cover computer-aided drug design using docking and QSAR studies. This course is designed to nurture skills and knowledge required for aspiring students, young biologists and research scholars to develop algorithms and tools in bioinformatics.


Week 1 : Introduction, DNA sequence analysis, DNA Databases
Week 2 : Protein structure and function, protein sequence databases, sequence alignment
Week 3 : PAM matrix, Global and local alignment, BLAST: features and scores
Week 4 : Multiple sequence alignment, Conservation score, phylogenetic trees
Week 5 : Protein sequence analysis, hydrophobicity profiles, non-redundant datasets
Week 6 : Protein secondary structures, Ramachandran plot, propensity, secondary structure prediction
Week 7 : Protein tertiary structure, Protein Data Bank, visualization tools, structural classification, contact maps
Week 8 : Protein structural analysis, protein structure prediction
Week 9 : Protein stability, energetic contributions, database, stabilizing residues, stability upon mutations
Week 10 : Protein folding rates, proteins interactions, binding site residues
Week 11 : Computer aided drug design, docking, screening, QSAR
Week 12 : Development of algorithms, awk programming, machine learning techniques, applications using WEKA

0 Student
Cost Free Online Course
Pace Upcoming
Subject Bioinformatics
Provider NPTEL
Language English
Calendar 12 weeks long

Disclosure: To support our site, Class Central may be compensated by some course providers.

+ Add to My Courses
FAQ View All
What are MOOCs?
MOOCs stand for Massive Open Online Courses. These are free online courses from universities around the world (eg. Stanford Harvard MIT) offered to anyone with an internet connection.
How do I register?
To register for a course, click on "Go to Class" button on the course page. This will take you to the providers website where you can register for the course.
How do these MOOCs or free online courses work?
MOOCs are designed for an online audience, teaching primarily through short (5-20 min.) pre recorded video lectures, that you watch on weekly schedule when convenient for you.  They also have student discussion forums, homework/assignments, and online quizzes or exams.

0 reviews for NPTEL's Bioinformatics: Algorithms and Applications

Write a review

Class Central

Get personalized course recommendations, track subjects and courses with reminders, and more.

Sign up for free